Method for producing adult liver progenitor cells
AssigneePromethera Biosciences S.A./N.V.
InventorsEtienne Sokal, Sarah Snykers, Tuba Baran, Kris Gellynck, Luca Falciola
Life of this patent
Estimating the term…
Abstract
Novel adult liver progenitor cells (called H2Stem Cells) have been have been characterized on the basis of a series of biological activities and markers. Methods for producing H2Stem Cells allow providing such cells in the form of adherent cells and three-dimensional cell clusters in suspension that can be differentiated into cells having strong liver-specific activities and/or that can be used for treating liver diseases or for evaluating the efficacy, the metabolism, and/or toxicity of a compound.
Claims12
An isolated, human adult liver progenitor cell wherein said cell is measured:
- (a) positive for α-smooth muscle actin (ASMA), albumin (ALB), and CD140b;
- and
- (b) negative for Sushi domain containing protein 2 (SUSD2) and Cytokeratin-19 (CK-19).
Dependencies are inferred from the claim text.