System and method for microdialysis imaging and regional fluidic delivery and control and applications of same

A system for microdialysis imaging and regional fluidic delivery and control for dialyzing/retrodialyzing/culturing/controlling/analyzing the living bio-object, wherein the living bio-object comprises cells, tissues, slices, or an organ of a living subject, comprising:

• a microdialysis imager comprising a imaging head having N pixels aligned in a pixel array for monitoring a state of a living bio-object that is in fluidic communication with the pixel array, N being a positive integer greater than one;
• and
• a fluidic module coupled to the microdialysis imager for delivering a fluidic substance to and collecting effluent from the living bio-object, the fluidic module comprising a fluidic network having a plurality of valves, a plurality of fluidic channels in fluidic communication with the plurality of valves and one or more pumps coupled to corresponding fluidic channels, and a microcontroller coupled to the fluidic network for individually controlling the plurality of valves and the one or more pumps of the fluidic network as so to operably and selectively deliver the fluidic substance to and continuously collect the effluent from the living bio-object responsive to the delivered fluidic substance via each pixel of the pixel array in real time.