UV graft on microfluidic devices
AssigneeBio-Rad Laboratories, Inc.
InventorJoshua Ritchey
Life of this patent
Estimating the term…
Abstract
Compositions, devices, and methods are disclosed for the covalent modification of polymer surfaces with graft copolymers having a blend of side chains. The halogenated acrylic and polyalkylene glycol acrylic side chains of the graft copolymer provide the polymer surface with high hydrophobicity, as well as increased resistance to biofouling with proteinaceous material. The polymer surfaces can be particularly useful in microfluidic devices and methods that involve the contacting of the covalently modified polymer surfaces with emulsions of aqueous droplets containing biological macromolecules within an oil carrier phase.
Claims19
A covalently modified polymer surface comprising a graft copolymer, wherein the graft copolymer comprises a backbone polymer, a polyalkylene glycol acrylic side chain, and a fluorinated acrylic side chain;
- wherein the covalently modified polymer surface has a water contact angle of greater than 100°;
- wherein the water contact angle changes by less than 10° upon exposure to an aqueous 1 mg/mL bovine serum albumin solution for 1 hour;
- and wherein the mass ratio of fluorinated acrylic side chain to polyalkylene glycol acrylic side chain in the graft copolymer ranges from 1:3 to 3:1.
Dependencies are inferred from the claim text.