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US 10,538,632 B1Granted
Shape-preserving polymeric replication of biological matter
AssigneeNational Technology & Engineering Solutions of Sandia, LLC
InventorBryan James Kaehr
Life of this patent
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Abstract
The present invention relates to a method of forming silica nanolayers on or within a biological sample, thereby capturing structural details that are present in the sample. The resultant silica composite or silica replica, in turn, can be employed as a template for a replica having those structural details captured in a polymer. Also provided herein are synthetic constructs including a polymeric replica, which can have any useful feature (e.g., oxygen-binding capacity).
Claims20
A method comprising:
- immersing a biological sample comprising one or more cells in a silicic acid solution comprising a silicic acid compound, wherein the biological sample is a sample from an animal source or a sample from a mammalian source;
- incubating the biological sample to provide penetration of the silicic acid compound into the biological sample, thereby forming one or more silica nanolayers on and within the biological sample, wherein the one or more silica nanolayers conform to a biological structure on and within the biological sample, thereby forming a silica composite;
- exposing the silica composite to one or more polymeric precursors, wherein the one or more polymeric precursors conform to at least one of the one or more silica nanolayers;
- and
- polymerizing the one or more polymeric precursors, thereby forming a polymerized silica replica or a polymerized silica composite.
2 more elements
A method comprising:
- immersing a biological sample comprising one or more cells in a silicic acid solution comprising a silicic acid compound, wherein the biological sample is a sample from a mammalian source;
- incubating the biological sample to provide penetration of the silicic acid compound into the biological sample, thereby forming one or more silica nanolayers on and within the biological sample, wherein the one or more silica nanolayers conform to a biological structure on and within the biological sample, thereby forming a silica composite;
- exposing the silica composite to one or more polymeric precursors, wherein the one or more polymeric precursors conform to at least one of the one or more silica nanolayers;
- and
- polymerizing the one or more polymeric precursors, thereby forming a polymerized silica replica or a polymerized silica composite.
2 more elements
Dependencies are inferred from the claim text.