CXCR4 binding molecules and methods of use thereof
AssigneeAdalta Limited
InventorsMichael Foley, Andrew Pow, Katherine Griffiths, Samantha Cobb, Katerina Viduka
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Abstract
The present disclosure relates to polypeptides (also referred to herein as CXCR4 binding molecules or polypeptides) that are directed against the G-coupled protein receptor CXCR4, also known as Fusin or CD184. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptide; to compositions, and in particular to pharmaceutical compositions that comprise such polypeptides and to uses of such polypeptides for therapeutic or diagnostic purposes.
Claims10
A polypeptide which binds to human C-X-C chemokine receptor type 4 (CXCR4), comprising a scaffold region and binding loop regions contained therein, the scaffold region comprising a sequence which has at least 90% identity to the scaffold region defined by amino acids 1 to 26, 33 to 79 and 88 to 97 of SEQ ID NO:1;
- and
- wherein the first binding loop region comprises a sequence represented by the formula SX1SX2X3R wherein
- X1 is G, K, L or Y;
- X2 is D, H, G or N;
- and
- X3 is I, V, M, F, Q or Y;
- or
- a conservative amino acid substitution thereof
- and/or
- wherein the second binding loop region comprises a sequence represented by the formula Y′1RY′2GY′3YRHRY′4LY′5LG wherein
- Y′1 is Y or W;
- Y′2 is T, V or I;
- Y′3 is G or A;
- Y′4 is A or Y;
- and
- Y′5 is V, R or K;
- or
- a conservative amino acid substitution thereof.
Dependencies are inferred from the claim text.