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US 10,538,587 B2Granted
Antibodies against notch 3
AssigneeNovartis AG
InventorsJoelle Deplazes-Lauber, Christy Fryer, Tiacen Hu, David Jenkins, Konstantin Petropoulos, Philippe Thiel
Life of this patent
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Abstract
The present disclosure relates to antibodies or fragments thereof that target at least one conformational epitope of a Notch 3 or mutant Notch 3 receptor; and compositions and methods of use thereof.
Claims6
An isolated antibody that binds to Notch 3 or a Notch3 binding fragment thereof, wherein the antibody or fragment comprises:
- a heavy chain variable region comprising the CDR1 amino acid sequence of SEQ ID NO:
- 23;
- the CDR2 amino acid sequence of SEQ ID NO:
- 24;
- the CDR3 amino acid sequence of SEQ ID NO:
- 25;
- and a light chain variable region comprising the CDR1 amino acid sequence of SEQ ID NO:
- 33;
- the CDR2 amino acid sequence of SEQ ID NO:
- 34;
- and the CDR3 amino acid sequence of SEQ ID NO:
- 35.
9 more elements
A single chain antibody that binds to Notch3 or a Notch 3 binding fragment thereof, wherein the antibody or fragment comprises:
- a heavy chain variable region comprising the CDR1 amino acid sequence of SEQ ID NO:23;
- the CDR2 amino acid sequence of SEQ ID NO:
- 24;
- the CDR3 amino acid sequence of SEQ ID NO:
- 25;
- a light chain variable region comprising the CDR1 amino acid sequence of SEQ ID NO:
- 33;
- the CDR2 amino acid sequence of SEQ ID NO:
- 34;
- and the CDR3 amino acid sequence of SEQ ID NO:
- 35.
8 more elements
Dependencies are inferred from the claim text.