Compositions and methods for treating fatty tissue buildup
AssigneeMhs Care-Innovation LLC
InventorsM. Michael Wolfe, Michael O. Boylan
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Abstract
The present disclosure is directed to the treatment of diseases or conditions involving the buildup of fatty tissues, such as obesity, metabolic syndrome, type II diabetes, etc. A composition containing a monoclonal antibody directed against gastric inhibitory polypeptide is administered. This results in a reduced rate of weight gain and a marked decrease in lipid synthesis and accumulation.
Claims13
A molecular antagonist of gastric inhibitory polypeptide (GIP) for treating fatty tissue buildup, comprising a light chain variable domain and a heavy chain variable domain, the heavy chain variable domain having at least 90% identity to an amino acid sequence of SEQ ID NO:
- 29;
- and
- wherein the heavy chain variable domain has a first CDR with 90% identity to the amino acid sequence of SEQ ID NO:
- 31, a second CDR with 85% identity to the amino acid sequence of SEQ ID NO:
- 32, and a third CDR with 90% identity to the amino acid sequence of SEQ ID NO:
- 33.
Dependencies are inferred from the claim text.