Anti-APOC3 antibodies and compositions thereof
AssigneeStaten Biotechnology B.V.
InventorsPaul DaSilva-Jardine, Hans de Haard
Life of this patent
Estimating the term…
Abstract
The instant disclosure provides antibodies that specifically bind to ApoC3 (e.g., human ApoC3) and antagonize ApoC3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
Claims30
An isolated antibody that specifically binds to human ApoC3, the antibody comprising a heavy chain variable region comprising complementarity determining regions CDRH1, CDRH2 and CDRH3, and a light chain variable region comprising complementarity determining regions CDRL1, CDRL2 and CDRL3, wherein:
- (a) CDRH1 comprises the amino acid sequence of SEQ ID NO:
- 3;
- (b) CDRH2 comprises the amino acid sequence of SEQ ID NO:
- 36;
- (c) CDRH3 comprises the amino acid sequence of SEQ ID NO:
- 10;
- (d) CDRL1 comprises the amino acid sequence of SEQ ID NO:
- 6;
- (e) CDRL2 comprises the amino acid sequence of SEQ ID NO:
- 7;
- and
- (f) CDRL3 comprises the amino acid sequence of SEQ ID NO:
- 14.
A heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 42.
A heavy chain comprising the amino acid sequence of SEQ ID NO:
- 68.
A light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 54.
A light chain comprising the amino acid sequence of SEQ ID NO:
- 74.
An isolated antibody that specifically binds to human ApoC3, the antibody comprising a heavy chain and a light chain, wherein the heavy chain comprises the amino acid sequence of SEQ ID NO:
- 68, and wherein the light chain comprises the amino acid sequence of SEQ ID NO:
- 74.
Dependencies are inferred from the claim text.