Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing conjugates thereof
AssigneesF. Hoffmann-La Roche AG, Institut Pasteur, Commissariat A L'energie Atomique Et Aux Energies Alternatives, Centre National de la Recherche Scientifique (CNRS)
InventorsPierre Lafaye, Sylvie Bay, Benoit Delatour, Marc Dhenain, Charles Duyckaerts, Tengfei Li, Matthias Vandesquille, Christian Czech, Fiona Grueninger
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Abstract
The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
Claims20
An isolated variant of the variable domain of a camelid heavy-chain antibody (VHH) of SEQ ID NO. 5, wherein said VHH variant is directed against the phosphorylated serine 422 of a phosphorylated tau protein, and wherein the amino acid sequence of said variant has at least 95% identity with the amino acid sequence SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.