Bispecific pertussis antibodies

A bispecific antibody that binds a pertussis toxin protein, comprising

• an immunoglobulin heavy chain and light chain of a humanized 1B7 antibody, wherein the immunoglobulin heavy chain derived from the humanized 1B7 antibody comprises a CDRH1 comprising an amino acid sequence of SEQ ID NO:
• 1, a CDRH2 comprising an amino acid sequence of SEQ ID NO:2, and a CDRH3 comprising an amino acid sequence of SEQ ID NO:
• 3;
• and the immunoglobulin light chain derived from the humanized 1B7 antibody comprises a CDRL1 comprising an amino acid sequence of SEQ ID NO:
• 6, a CDRL2 comprising an amino acid sequence of SEQ ID NO:
• 7, and a CDRL3 comprising an amino acid sequence of SEQ ID NO:
• 8;
• and
• an immunoglobulin heavy chain and light chain of a humanized 11E6 antibody, wherein the immunoglobulin heavy chain derived from the humanized 11E6 antibody comprises a CDRH1 comprising an amino acid sequence of SEQ ID NO:
• 11, a CDRH2 comprising an amino acid sequence of SEQ ID NO:
• 12, and a CDRH3 comprising an amino acid sequence of SEQ ID NO:
• 13;
• and the immunoglobulin light chain derived from the humanized 11E6 antibody comprises a CDRL1 comprising an amino acid sequence of SEQ ID NO:
• 16, a CDRL2 comprising an amino acid sequence of SEQ ID NO:
• 17, and a CDRL3 comprising an amino acid sequence of SEQ ID NO:
• 18,
• wherein the immunoglobulin heavy chain derived from the humanized 1B7 antibody comprises a mutation at T366, numbered according to the EU index as in Kabat and wherein the immunoglobulin heavy chain derived from the humanized 11E6 antibody comprises a mutation at Y407, numbered according to the EU index as in Kabat.