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US 10,538,578 B2Granted
Agents for influenza neutralization
AssigneeMassachusetts Institute of Technology
InventorsS. Raguram, Viswanathan Sasisekharan, Venkataramanan Soundararajan, Ram Sasisekharan, Vidya Subramanian, Kannan Tharakaraman
Life of this patent
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Abstract
The present invention provides antibodies (e.g., monoclonal antibodies, human antibodies, humanized antibodies, etc.), which bind to multiple influenza strains. Such antibodies are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of influenza.
Claims16
A composition comprising an engineered antibody that:
- (a) has a heavy chain variable region that shows at least 99% substantial sequence homology with that of heavy chain variable region of SEQ ID NO:
- 1;
- and
- (b) has a light chain variable region that shows at least 99% substantial sequence homology to one of SEQ ID NOs:
- 33-43.
2 more elements
A method of treating a subject, the method comprising steps of:
- administering to a subject suffering from or susceptible to influenza infection therapeutically effective amount of an antibody agent that:
- (a) has a heavy chain variable region that:
- (i) shows at least 99% substantial sequence homology with that of heavy chain variable region of SEQ ID NO:
- 1;
- and
- (ii) shares at least one CDR with SEQ ID NO:
- 1;
- and
- (b) has a light chain variable region that shows at least 99% substantial sequence homology to one of SEQ ID NOs:
- 33-43.
7 more elements
Dependencies are inferred from the claim text.