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US 10,538,571 B2Granted
Compositions and methods for neurological diseases
AssigneeCoda Biotherapeutics, Inc.
InventorsKenneth P. Greenberg, Orion Keifer, Jr., Stefanie Makinson, Anthony Lau
Life of this patent
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Abstract
Compositions and methods are provided for modulating the activity of cells using engineered receptors, polynucleotide encoded engineered receptors, and gene therapy vectors comprising polynucleotides encoding engineered receptors. These compositions and methods find particular use in modulating the activity of neurons, for example in the treatment of disease or in the study of neuronal circuits.
Claims28
An engineered receptor, wherein the engineered receptor is a chimeric ligand gated ion channel (LGIC) receptor and comprises
- (a) a ligand binding domain derived from the human α7 nicotinic acetylcholine receptor (α7-nAChR) and comprising a Cys-loop domain from the human Glycine receptor α1 subunit;
- and
- (b) an ion pore domain derived from the human Glycine receptor α1 subunit.
Dependencies are inferred from the claim text.