Methods and compositions of a follicle stimulating hormone receptor immunoreceptor
AssigneeThe Trustees of the University of Pennsylvania
InventorsDaniel J. Powell, Jr., Caitlin Stashwick, Katarzyna Urbanska
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Abstract
The present invention relates to compositions and methods for diagnosing and treating diseases, disorders or conditions associated with dysregulated expression of FSHR. The invention provides novel peptides that specifically bind to Follicle-stimulation hormone receptor (FSHR).
Claims12
An isolated nucleic acid sequence encoding a follicle-stimulating hormone receptor (FSHR) binding immunoreceptor (IR) comprising a FSHR binding domain, a transmembrane domain, and a signaling domain, wherein the FSHR binding domain comprises a follicle-stimulating hormone (FSH) or fragment thereof, a FSHR antagonist or fragment thereof, or an anti-FSHR agonist or fragment thereof, wherein the FSHR binding domain is encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOs:
- 10, 12, 14, 16, 18 and 20.
Dependencies are inferred from the claim text.