Anti-HIV peptides
AssigneesColorado State University Research Foundation, University of Rochester
InventorsBrian R. McNaughton, David W. Crawford, Joseph E. Wedekind, Ivan A. Belashov
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Abstract
Simple β-hairpin peptides in linear and cyclic form that specifically bind to HIV-1 Trans-Activation Response element (HIV-1 TAR), as well as compositions and use thereof are described.
Claims34
An isolated peptide comprising an amino acid sequence, the amino acid sequence consisting of the amino acid sequence of SEQ ID NO:
- 2, wherein the isolated peptide specifically binds to HIV-1 trans-activation responsive element.
An isolated peptide comprising an amino acid sequence, the amino acid sequence consisting of the amino acid sequence selected from the group consisting of SEQ ID NOs:
- 5-24 wherein the isolated peptide specifically binds to HIV-1 trans-activation responsive element.
A cyclic peptide comprising an amino acid sequence, the amino acid sequence comprising the 13 amino acid residues at position 4 to position 16 of one of SEQ ID NOs:
- 7-24.
A cyclic peptide comprising an amino acid sequence, the amino acid sequence comprising the amino acid sequence of one or SEQ ID NOs:
- 5-24.
Dependencies are inferred from the claim text.