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US 10,538,549 B2Granted
NNA-DNA adducts as biomarkers for detecting exposure to thirdhand smoke
AssigneeThe Regents of the University of California
InventorsBo Hang, Ahmed Chenna
Life of this patent
Estimating the term…
Abstract
NNA-derived specific adducts represent an integrated biomarker of exposure to thirdhand smoke (THS) as NNA is unique to THS. The NNA-dG covalent binding adduct could serve as such a biomarker, and play a role in identifying individuals exposed to THS, thus providing critical information for early detection and prevention.
Claims13
A method for detection of prior thirdhand smoke (THS) exposure in a sample, comprising the steps of
- a. obtaining a biological or non-biological sample, wherein said sample is not a biological sample obtained from a firsthand smoker or non-smokers exposed to secondhand smoke (SHS);
- b. providing a detector which detects the presence or level of a 2-deoxyguanosine (dG) adduct, and 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal (NNA) in a sample;
- and
- c. detecting the presence of said dG adduct, and NNA by the detector above standard baseline levels;
- wherein the dG adduct detected having the structure of:
2 more elements
Dependencies are inferred from the claim text.