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US 10,538,544 B1Granted
Method for administering cisplatin and a thiocyanate complex to treat ovarian cancer
AssigneeKing Fahd University of Petroleum and Minerals
InventorsAnvarhusein A. Isab, Muhammad Altaf, Muhammad Ali Ehsan, Khalid Omer
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Abstract
The invention is directed to platinum(II) complexes comprising dithiocarbamates and methods for treating cancer using these complexes.
Claims6
A method for treating cisplatin-resistant ovarian cancer in a subject in need thereof, the method comprising:
- first administering cisplatin to the subject and diagnosing a cisplatin-resistant ovarian cancer by at least one of high ERCC1 mRNA levels, overexpression of HER-2/neu, activation of the PI3-K/Akt pathway, loss of p53 function, and overexpression of antiapoptotic bcl-2;
- then
- administering to the subject an amount of at least one complex selected from the group consisting of complex (1):
- [Pt(S2CNi Bu2)2], complex (2):
- [Pt(S2CNBn2)2].py, where Bn=benzyl and py=pyridine, and complex (3):
- [Pt(S2CNi Pr2)2] sufficient to treat the cisplatin-resistant ovarian cancer.
3 more elements
Dependencies are inferred from the claim text.