Cyclopenta[d]pyrimidines and substituted cyclopenta[d]pyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin inhibitors, and pyrrolopyrimidines as targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibition and antitumor agents
AssigneeDuquesne University of the Holy Spirit
InventorAleem Gangjee
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Abstract
The present invention provides a compound of Formula II, and salts thereof, and a pharmaceutical composition comprising a compound of Formula II: wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, and wherein R3 is hydrogen, an alkyl group having from one to ten carbon atoms, or a halogen. Preferably the compound of Formula II includes wherein R3 is a halogen, and most preferably wherein the halogen is chlorine. Methods of treating a patient with cancer with these compounds are also provided.
Claims7
A compound of Formula II, and salts thereof:
- wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, and wherein R3 is a halogen.
A pharmaceutical composition comprising a compound of Formula II and a pharmaceutically acceptable salt thereof:
- wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, and wherein R3 is a halogen.
Dependencies are inferred from the claim text.