US 10,538,515 B2 · Isatin-derived compounds, use of the compounds for the treatment of AIDS and method of treatment using these compounds

Abstract

This invention relates to HIV-inhibiting compounds consisting of other Formulae I, II or III isatin derivatives, as shown below (Formulae I, II and III), whereby in Formulae I, II and III, R1 is selected from H, CH3 or Cl; R2 is selected from one of the following radicals: zidovudine, amprenavir or an acyclic phosphonate chain, as shown below. This invention also relates to the use and treatment method using the Formulae I, II and III compounds. According to this invention, these compounds are also used for the treatment of infections caused by HBV or co-infection caused by HIV and HBV.

Claims10

Dependent claims

Compound derived from isatin, wherein the compound is a compound of Formulae I, II, or III, as shown below;

whereby in Formulae I, II, and III:
R1 is selected from the group consisting of:
H, CH3, and Cl;
and
R2 is selected from the group consisting of:
a radical of zidovudine, a radical of amprenavir, and an acyclic phosphonate chain, as shown below:

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/099,901Filed 10 May 2016

Published

US 2019/0177305 A113 Jun 2019

Granted

21 Jan 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07D 405/14
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having…:…
A61K 31/4192
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: 1,2,3-Triazoles
A61K 31/513
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61P 31/18
For RNA viruses: for HIV

Isatin-derived compounds, use of the compounds for the treatment of AIDS and method of treatment using these compounds

Life of this patent

Isatin-derived compounds, use of the compounds for the treatment of AIDS and method of treatment using these compounds

Life of this patent

Abstract

Claims10