Aminoacylindazole immunomodulators for treatment of autoimmune diseases

A compound of formula I or formula II:

• wherein
• R1 is an optionally substituted bicyclic ring system chosen from an optionally substituted indole, isoindole, oxindole, tetrahydroindole, tetralin, indoline, isoindoline, tetrahydroquinoline, tetrahydroisoquinoline, 3,4-dihydro-1H-isochromene, 3,4-dihydro-2H-chromene, benzofuran, dihydrobenzofuran, tetrahydrobenzofuran, benzothiophene, tetrahydrobenzothiophene, indazole, tetrahydroindazole, 2,3-dihydro-1H-indene, naphthalene, tetrahydronaphthalene, and isochroman, said ring system attached to the carbonyl through a carbon, or, when R2 is amino, R1 may additionally be meta- or para-substituted phenyl or an optionally substituted monocyclic heteroaryl ring;
• wherein R1 is optionally substituted with one or more of halogen, hydroxy, amino, cyano, (C1-C8)hydrocarbyl, (C1-C8)hydrocarbyloxy, (C1-C4)alkylamino, di(C1-C4)alkylamino, (C1-C4)acylamino, (C1-C4)alkylsulfonyl, (C1-C4)fluoroalkyl, (C1-C4)fluoroalkoxy, (C1-C6)oxaalkyl, (C3-C6)carbocycle, and (C1-C4)alkenyl;
• R2 is chosen from hydrogen, amino and methyl;
• and
• R3 and R4 are chosen independently from hydrogen, halogen, hydroxy, amino, cyano, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)alkylamino, di(C1-C4)alkylamino, (C1-C7)acylamino, ((C1-C7)hydrocarbyloxy)carbonylamino, (C1-C4)fluoroalkyl, (C1-C4)fluoroalkoxy, and (C1-C6)oxaalkyl, or, taken together, R3 and R4 on adjacent carbons form a double bond.