Kinase modulators

A compound of the formula:

• or a tautomer thereof, N-oxide thereof, pharmaceutically acceptable ester thereof, prodrug thereof, or pharmaceutically acceptable salt thereof, wherein
• R is independently selected from —ORa;
• R1 and R2 may be the same or different and are independently selected from hydrogen, halogen, and substituted or unsubstituted C1-6 alkyl, or both R1 and R2 directly bound to a common atom, may be joined to form a substituted or unsubstituted saturated or unsaturated 3-10 member ring (including the carbon atom to which R1 and R2 are bound), which may optionally include one or more heteroatoms which may be the same or different and are selected from O, NRa and S;
• Cy1 is a monocyclic group selected from substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
• Cy2 is selected from substituted heterocyclic group and substituted or unsubstituted heteroaryl;
• L1 is selected from —S(═O)q— and —NRa—;
• each occurrence of Ra is selected from hydrogen, substituted or unsubstituted (C1-6)alkyl, or —NRcRd (wherein Rc and Rd are independently hydrogen, halogen, hydroxy, cyano, substituted or unsubstituted (C1-6)alkyl, and (C1-6)alkoxy);
• and
• q is 0, 1 or 2.

A compound of formula

• or a tautomer thereof, N-oxide thereof, pharmaceutically acceptable ester thereof, prodrug thereof, or pharmaceutically acceptable salt thereof, wherein
• each occurrence of R is independently selected from hydrogen, halogen, —OH, CN, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-8 cycloalkyl, and substituted or unsubstituted heterocyclic group;
• both R1 and R2 are directly bound to a common atom to form an oxo group (═O);
• Cy1 is substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
• Cy2 is
• wherein X is CR3;
• R3 is independently selected from hydrogen, hydroxy, halogen, carboxyl, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heteroaryl, substituted heterocyclylalkyl ring, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted guanidine, —COORx, —C(O)Rx, —C(S)Rx, —C(O)NRxRy, —C(O)ONRxRy, —NRxCONRyRz, —N(Rx)SORy, —N(Rx)SO2Ry, —(═N—N(Rx)Ry), —NRxC(O)ORy, —NRxRy, —NRxC(O)Ry-, —NRxC(S)Ry—NRxC(S)NRyRz, —SONRxRy—, —SO2NRxRy—, —ORx, —ORxC(O)NRyRz, —ORxC(O)ORy—, —OC(O)Rx, —OC(O)NRxRy, —RxNRyC(O)Rz, —RxORy, —RxC(O)ORy, —RxC(O)NRyRz, —RxC(O)Rx, —RxOC(O)Ry, —SRx, —SORx, —SO2Rx, and —ONO2, wherein Rx, Ry and Rz in each of the above groups can be hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted amino, substituted or unsubstituted heteroaryl, substituted heterocyclylalkyl ring, substituted or unsubstituted heteroarylalkyl, or substituted or unsubstituted heterocyclic ring, or any two of Rx, Ry and Rz may be joined to form a substituted or unsubstituted saturated or unsaturated 3-10 membered ring, which may optionally include heteroatoms which may be the same or different and are selected from O, NRw (wherein Rw is hydrogen or substituted or unsubstituted alkyl) or S;
• L1 is —NRa—;
• each occurrence of Ra is selected from hydrogen, halogen, hydroxy, cyano, substituted or unsubstituted (C1-6)alkyl, —NRcRd (wherein Rc and Rd are independently hydrogen, halogen, hydroxy, cyano, substituted or unsubstituted (C1-6)alkyl, and (C1-6)alkoxy) and —ORc (wherein Rc is substituted or unsubstituted (C1-6)alkyl);
• n is an integer from 1 to 4;
• and
• q is 0, 1 or 2.

A compound of the formula

• or a tautomer thereof, N-oxide thereof, pharmaceutically acceptable ester thereof, prodrug thereof, or pharmaceutically acceptable salt thereof, wherein
• each occurrence of R is independently selected from —ORa;
• R1 and R2 may be the same or different and are independently selected from hydrogen, halogen, and substituted or unsubstituted C1-6 alkyl, or both R1 and R2 directly bound to a common atom, may be joined to form a substituted or unsubstituted saturated or unsaturated 3-10 member ring which may optionally include one or more heteroatoms which may be the same or different and are selected from O, NRa and S;
• Cy1 is a monocyclic group selected from substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
• Cy2 is selected from substituted or unsubstituted aryl and substituted heteroaryl;
• L1 is selected from —S(═O)q— and —NRa—;
• each occurrence of Ra is selected from hydrogen and substituted or unsubstituted (C1-6) alkyl;
• n is an integer from 1 to 4;
• and
• q is 0, 1 or 2.

A compound of formula

• or a tautomer thereof, N-oxide thereof, pharmaceutically acceptable ester thereof, prodrug thereof, or pharmaceutically acceptable salt thereof, wherein
• each occurrence of R is independently selected from hydrogen, halogen, —ORa, CN, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-8 cycloalkyl, and substituted or unsubstituted heterocyclic group;
• both R1 and R2 are directly bound to a common atom to form an oxo group (═O);
• Cyl is a monocyclic group selected from substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
• Cy2 is selected from substituted or unsubstituted aryl and substituted or unsubstituted bicyclic heteroaryl;
• L1 is selected from —S(═O)q— and —NRa—;
• each occurrence of Ra is selected from hydrogen, halogen, hydroxy, cyano, substituted or unsubstituted (C1-6)alkyl, —NRcRd (wherein Rc and Rd are independently hydrogen, halogen, hydroxy, cyano, substituted or unsubstituted (C1-6)alkyl, and (C1-6)alkoxy) and —ORc(wherein Rc is substituted or unsubstituted (C1-6)alkyl);
• n is an integer from 1 to 4;
• and
• q is0,1or2.