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US 10,538,495 B2Granted
Modulators of indoleamine 2,3-dioxygenase
AssigneeGlaxoSmithKline Intellectual Property Development Limited
InventorsBrian Alvin Johns, Wieslaw Mieczyslaw Kazmierski, Martha Alicia De La Rosa, Vicente Samano
Life of this patent
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Abstract
Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases.
Claims2
A compound of Formula II
- or a pharmaceutically acceptable salt thereof, wherein
- in each depicted ring containing Xs, either each X is CH to form a benzene ring, or one X is N while the others are CH to form a pyridine ring;
- the depicted tetrazole may optionally be substituted by a CH2OH, wherein said CH2OH is optionally converted into a prodrug by converting the CH2OH group to a CH2OC(O)CH3, CH2OC(O)C(C1-4alkyl)3, or OP(O)(OH)2 group, or OP(O)(OC1-4alkyl)2 group;
- R3 is phenyl, or a 4 to 6-membered heterocycle or heteroaryl containing 1 to 4 heteroatoms selected from N, S, and O;
- and wherein said phenyl, heterocycle, or heteroaryl, may optionally substituted by one to three C1-3alkyl groups each of which is optionally substituted by 1-3 halogens.
2 more elements
Dependencies are inferred from the claim text.