Quinolinone or quinazolinone comprising antibiofilm compositions, compounds and methods and uses relating thereto
AssigneeUniversity College Cork, National University of Ireland
InventorsFergal O'Gara, Jerry F. Reen, Gerard McGlacken
Life of this patent
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Abstract
An antibiofilm composition comprising a compound of formula (A1), (A2) or (A3): wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, nitro, sulfoxy, thiol, carboxy, alkyl carboxy and amido; and X may be O or S, wherein the composition does not comprise a compound of formula (B1) or (B2):
Claims13
An antibiofilm composition comprising a compound of formula (A2):
- wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, nitro, sulfoxy, thiol, carboxy, alkyl carboxy and amido;
- and X may be O or S, wherein the composition does not comprise a compound of formula (B1) or (B2):
- wherein the composition is effective against biofilms formed by fungi, and is a pharmaceutical preparation that further comprises one or more additional antifungal agents.
An antibiofilm composition comprising a compound of formula (A2):
- wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, nitro, sulfoxy, thiol, carboxy, alkyl carboxy and amido;
- and X may be O or S, wherein the composition does not comprise a compound of formula (B1) or (B2):
- which composition is effective against biofilms formed by fungi and is a contact lens solution that further comprises one or more additional antifungal agents.
A medical device having a coating on at least a portion thereof;
- wherein the coating comprises an antibiofilm compound of formula (A2):
- wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, nitro, sulfoxy, thiol, carboxy, alkyl carboxy and amido;
- and X may be O or S, wherein the composition does not comprise a compound of formula (B1) or (B2):
- wherein the composition is effective against biofilms formed by fungi.
Dependencies are inferred from the claim text.