Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof

A compound of formula (I)

• wherein
• R is selected from the group consisting of
• H, F, Cl, Br, I, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-6-cycloalkyl, NC—, HNRN—C(═O)—, C1-4-alkyl-NRN—C(═O)—, C3-6-cycloalkyl-NRN—C(═O)—, heterocyclyl-NRN—C(═O)—, heteroaryl-NRN—C(═O)—, HOOC—, C1-4-alkyl-O—C(═O)—, O2N—, HRNN—, C1-4-alkyl-RNN—, C1-4-alkyl-C(═O)NRN—, C3-6-cycloalkyl-C(═O)NRN—, heterocyclyl-C(═O)NRN—, heteroaryl-C(═O)NRN—, C1-4-alkyl-S(═O)2NRN—, C3-6-cycloalkyl-S(═O)2NRN—, heterocyclyl-S(═O)2NRN—, heteroaryl-S(═O)2NRN—, HO—, C1-6-alkyl-O—, HOOC—C1-3-alkyl-O—, C3-6-cycloalkyl-C1-3-alkyl-O—, heterocyclyl-C1-3-alkyl-O—, phenyl-C1-3-alkyl-O—, C3-6-cycloalkyl-O—, heterocyclyl-O—, heteroaryl-O—, C1-4-alkyl-S—, C3-6-cycloalkyl-S—, heterocyclyl-S—, C1-4-alkyl-S(═O)—, C3-6-cycloalkyl-S(═O)—, heterocyclyl-S(═O)—, C1-4-alkyl-S(═O)2—, C3-6-cycloalkyl-S(═O)2—, heterocyclyl-S(═O)2—, phenyl-S(═O)2—, heteroaryl-S(═O)2—, HNRN—S(═O)2—, C1-4-alkyl-NRN—S(═O)2—, heterocyclyl, phenyl, and heteroaryl,
• wherein each alkyl, cycloalkyl, and heterocyclyl group or sub-group within the groups forming R is optionally substituted with 1 or more F atoms and optionally substituted with 1 to 3 groups independently selected from Cl, C1-3-alkyl, NC—, (RN)2N—, HO—, C1-3-alkyl-O—, and C1-3-alkyl-S(═O)2—;
• and
• wherein each phenyl and heteroaryl group or sub-group within the groups forming R is optionally substituted with 1 to 5 substituents independently selected from F, Cl, C1-3-alkyl, HF2C—, F3C—, NC—, (RN)2N—, HO—, C1-3-alkyl-O—, F3C—O—, and C1-3-alkyl-S(═O)2—;
• wherein each heterocyclyl group or sub-group within the groups forming R is selected from
• a cyclobutyl group wherein 1 CH2 group is replaced by —NRN— or —O—;
• a C5-6-cycloalkyl group wherein 1 CH2 group is replaced by —C(═O)—, —NRN—, —O—, —S— or —S(═O)2— and/or 1 CH group is replaced by N;
• a C5-6-cycloalkyl group wherein 1 CH2 group is replaced by —NRN— or —O—, a second CH2 group is replaced by —NRN—, —C(═O)— or —S(═O)2— and/or 1 CH group is replaced by N;
• and
• a C5-6-cycloalkyl group wherein 2 CH2 groups are replaced by —NRN— or 1 CH2 group by —NRN— and the other by —O— and a third CH2 group is replaced by —C(═O)— or —S(═O)2— and/or 1 CH group is replaced by N;
• wherein each heteroaryl group or sub-group within the groups forming R is selected from tetrazolyl and a 5- or 6-membered heteroaromatic ring which contains 1, 2, or 3 heteroatoms independently of each other selected from ═N—, —NRN—, —O—, and —S—, wherein in heteroaromatic groups containing a —HC═N— unit this group is optionally replaced by —NRN—C(═O)—;
• wherein in heteroaryl and heterocyclyl rings with one or more NH groups, each of said NH groups is replaced by NRN;
• R1 is selected from the group consisting of H, F, Cl, C1-4-alkyl, C3-6-cycloalkyl-, HO—C1-4-alkyl, C1-4-alkyl-O—C1-4-alkyl, NC—, HO—, C1-4-alkyl-O—, C3-6-cycloalkyl-O—, C1-4-alkyl-S—, C1-4-alkyl-S(O)—, and C1-4-alkyl-S(O)2—,
• wherein any alkyl and cycloalkyl group or sub-group within the groups forming R1 is optionally substituted with 1 or more F atoms, and wherein multiple R1 may be identical or different if m is 2, 3 or 4;
• m is an integer selected from 1, 2, 3, and 4;
• R2 is selected from the group consisting of H, F, Cl, C1-4-alkyl, NC—, and C1-4-alkyloxy, wherein any alkyl group or sub-group within the groups forming R2 is optionally substituted with 1 or more F atoms, and wherein multiple R2 may be identical or different if n is 2 or 3;
• R3 is selected from the group consisting of H, F, Cl, C1-4-alkyl, NC—, and C1-4-alkyl-O—, wherein each alkyl group or sub-group within the groups forming R3 is optionally substituted with 1 or more F atoms;
• n is an integer selected from 1, 2, and 3;
• RN is independently of each other selected from the group consisting of H, C1-4-alkyl, HO—C1-4-alkyl-(H2C)—, C1-3-alkyl-O—C1-4-alkyl-, C1-4-alkyl-C(═O)—, C1-4-alkyl-NH—C(═O)—, C1-4-alkyl-N(C1-4-alkyl)-C(═O)—, C1-4-alkyl-O—C(═O)—, and C1-4-alkyl-S(═O)2—,
• wherein each alkyl group or sub-group within the groups forming RN is optionally substituted with 1 or more F atoms;
• wherein in any definition mentioned hereinbefore, if not specified otherwise, any alkyl group or sub-group may be straight-chained or branched,
• or a salt thereof.