Sulfonylureas and related compounds and use of same
AssigneesThe University of Queensland, The Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin
InventorsLuke O'Neill, Rebecca Coll, Matthew Cooper, Avril Robertson, Kate Schroder
Life of this patent
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Abstract
The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.
Claims34
A compound of formula (II), or a pharmaceutically acceptable salt, solvate or prodrug thereof:
- wherein A, B, D and E are independently selected from C, N, O, S and Se, but at least one thereof is C and at least one thereof is N;
- each dashed line may represent a bond;
- each incidence of R6 is independently selected from the group consisting of hydrogen, halide, cyano, C1-C6 alkyl, C1-C6 alkylamino, C1-C6 alkylhydroxy, C3-C6 cycloalkyl, alkylphenyl, phenyl, benzyl, C1-C6 ester, C2-C6 alkenyl, C1-C6 trifluoroalkyl and C1-C6 alkoxy, each of which may be optionally substituted, as appropriate, or R6 is a fluorescent group;
- and
- R2 is selected from a 2,6-dialkylphenyl, a 2,6-dialkyl-4-halophenyl, a 2,6-dicycloalkylphenyl, a 2,6-dicycloalkyl-4-halophenyl, and:
- wherein each incidence of Y is independently selected from C, N, S and O, which may be optionally substituted as appropriate;
- and
- R5 is selected from the group consisting of hydrogen, halo, cyano, amide, sulphonamide, acyl, hydroxyl, C1-C6 alkyl, C1-C6 haloalkyl, C3-C5 cycloalkyl and C1-C6 alkoxy, all of which groups may be optionally substituted, as appropriate, with halo, cyano or C1-C6 alkoxy.
Dependencies are inferred from the claim text.