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US 10,538,479 B2Granted
Process for the preparation of indanamine derivatives and new synthesis intermediates
AssigneeOlon S.P.A.
InventorsCorrado Colli, Alessandro Agosti, Stefano Maiorana, Federica Colombo, Giorgio Bertolini
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Abstract
Subject-matter of the invention is a process for the preparation of key intermediates in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
Claims15
A process for the preparation of a compound of formula (I)
- or salts thereof, wherein R is a hydrogen atom or an amine protecting or activating group, comprising reacting 1H-inden-2-yl-amine of formula (II)
- or a salt thereof, with N-bromosuccinimide (NBS) in water, wherein R is an amine protecting or activating group.
A process for the preparation of a compound of formula (I)
- or salts thereof, wherein R is a hydrogen atom or an amine protecting or activating group, comprising reacting 1H-inden-2-yl-amine of formula (II)
- or a salt thereof, with N-bromosuccinimide (NBS) in water, and desalifying the so-obtained bromide compound and/or converting it in another salt and/or in a derivative, wherein R is an amine protecting or activating group.
Dependencies are inferred from the claim text.