Methods and systems for providing protection against harmful materials

A single-person, hand carriable, and air tight Class-3 glove box for handling harmful material weighing less than 75 pounds, the glove box comprising:

• a top component;
• a tank component comprising a lightweight, rigid plastic and comprising an upper edge removably attached to the top component, a floor and a plurality of external, vertical walls comprising rigid, external vertical ribs, the vertical walls including a plurality of passageways for removable connection to other components, with all unused passageways covered with a blank connector to maintain the airtight integrity of the glove box, said top component and tank component configured to maintain a negative pressure;
• at least one pre-filter element component and a HEPA filter removably attached to one of the passageways for filtering air associated with the glove box, and an exhaust HEPA filter removably attached to an exhaust opening;
• an input/output component removably attached to one of the passageways for introducing harmful material including bacteriological agents, to, or extracting such harmful material from, the glove box,
• wherein the top component, tank component at least one pre-filter element, HEPA filters and input/output component are configured as the single-person, hand carriable, and air tight Class-3 glove box for handling harmful material weighing less than 75 pounds.