Resorbable, amino acid-based poly(ester urea)s scaffold for vascular graft tissue engineering

An amino acid-based poly(ester urea) vascular graft having a tubular structure comprising an amino acid-based poly(ester urea), said amino acid-based poly(ester urea)comprising:

• a first amino acid residue selected from L-leucine, L-isoleucine, L-valine or combinations thereof attached to a hydrocarbylene group having from 10 to 12 carbon atoms through an ester group;
• and
• a second amino acid residue defined by the formula:
• where R is a pendent functional group, wherein said second amino acid residue is attached to a hydrocarbylene group having from 10 to 12 carbon atoms through an ester group.

A method of preparing an amino acid-based poly(ester urea) vascular graft comprising

• (i) providing a charged solution of amino acid-based poly(ester urea) wherein said amino acid-based poly(ester urea) is defined by the following formula;
• where each J is individually a L-leucine, L-isoleucine, or L-valine side chain, at least one X2 is a proteinogenic amino acid or non-proteinogenic amino acid side chain defined by the formula:
• where R is a pendent functional group;
• each n is individually about 10 to 12 units;
• m is from about 10 to about 500 units;
• and o is from about 10 to about 500 units;
• (ii) providing a grounded mandrel coated with a dissolvable coating;
• (iii) electrospinning the charged solution of amino acid-based poly(ester urea) onto the dissolvable coating of the grounded mandrel to produce a tubular structure,
• (iv) dissolving the dissolvable coating;
• and
• (v) removing the tubular structure from the mandrel.