Cyclic urea compounds as granzyme B inhibitors

A compound having Formula (I):

• or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein:
• R1 is a heteroaryl group selected from
• (a) 1,2,3-triazolyl, and
• (b) 1,2,3,4-tetrazolyl;
• n is 1 or 2;
• R2 is selected from
• (a) hydrogen,
• (b) C1-C6 alkyl, and
• (c) C3-C6 cycloalkyl;
• R3 is selected from
• (a) hydrogen,
• (b) C1-C4 alkyl optionally substituted with a carboxylic acid, carboxylate, or carboxylate C1-C8 ester group, an amide optionally substituted with an alkylheteroaryl group, or a heteroaryl group;
• Z is an acyl group selected from the group
• wherein
• Y is hydrogen, heterocycle, —NH2, or C1-C4 alkyl;
• R4 is selected from
• (i) C1-C12 alkyl,
• (ii) C1-C6 heteroalkyl optionally substituted with C1-C6 alkyl,
• (iii) C3-C6 cycloalkyl,
• (iv) C6-C10 aryl,
• (v) heterocyclyl,
• (vi) C3-C10 heteroaryl,
• (vii) aralkyl, and
• (viii) heteroalkylaryl;
• R5 is heteroaryl or —C(═O)—R10,
• wherein R10 is selected from
• (i) C1-C12 alkyl optionally substituted with C6-C10 aryl, C1-C10 heteroaryl, amino, or carboxylic acid,
• (ii) C1-C10 heteroalkyl optionally substituted with C1-C6 alkyl or carboxylic acid,
• (iii) C3-C6 cycloalkyl optionally substituted with C1-C6 alkyl, optionally substituted C6-C10 aryl, optionally substituted C3-C10 heteroaryl, amino, or carboxylic acid,
• (iv) C6-C10 aryl optionally substituted with C1-C6 alkyl, optionally substituted C6-C10 aryl, optionally substituted C3-C10 heteroaryl, amino, or carboxylic acid,
• (v) heterocyclyl,
• (vi) C3-C10 heteroaryl,
• (vii) aralkyl, and
• (viii) heteroalkylaryl.