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US 10,537,649 B2Granted
MRI imaging of amyloid plaque using liposomes
AssigneeTexas Children's Hospital
InventorsAnanth Annapragada, Eric A. Tanifum, Mayank Srivastava
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Abstract
Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid-polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-β plaque deposits characteristic of Alzheimer's Disease.
Claims18
A liposomal composition, comprising:
- a membrane, comprising:
- a phospholipid-polymer-aromatic conjugate, the aromatic moiety in the phospholipid-polymer-aromatic conjugate being represented by:
- wherein:
- R2 is a linking group comprising 1 to 6 carbon atoms that is one of:
- alkylene or alkoxyalkylene.
2 more elements
A method for imaging amyloid deposits in a patient, the method comprising:
- introducing into the patient a detectable quantity of a liposomal composition, the liposomal composition comprising:
- a membrane, comprising:
- a phospholipid-polymer-aromatic conjugate, the aromatic moiety in the phospholipid-polymer-aromatic conjugate being represented by:
- wherein:
- R2 is a linking group comprising 1 to 6 carbon atoms that is one of:
- alkylene or alkoxyalkylene;
- a nonradioactive magnetic resonance imaging (MM) contrast enhancing agent at least one of encapsulated by or bound to the membrane;
- allowing sufficient time for the liposomal composition to be associated with one or more amyloid deposits;
- and
- detecting the liposomal composition associated with the one or more amyloid deposits.
7 more elements
A kit for imaging amyloid deposits in a patient, the kit comprising:
- a liposomal composition, the liposomal composition comprising:
- a membrane, comprising:
- a phospholipid-polymer-aromatic conjugate, the aromatic moiety in the phospholipid-polymer-aromatic conjugate being represented by:
- wherein:
- R2 is a linking group comprising 1 to 6 carbon atoms that is one of:
- alkylene or alkoxyalkylene;
- a nonradioactive magnetic resonance imaging (MM) contrast enhancing agent at least one of encapsulated by or bound to the membrane;
- Instructions, the instructions directing a user to
- introduce into the patient a detectable quantity of the liposomal composition;
- allow sufficient time for the liposomal composition to be associated with one or more amyloid deposits;
- and
- detect the liposomal composition associated with the one or more amyloid deposits.
9 more elements
Dependencies are inferred from the claim text.