Ultrasound delivery of nanoparticles

A method of delivering a composition to a sebaceous gland and performing ablation, comprising:

• topically applying a solution of unassembled plasmonic nanoparticles to a skin surface,
• targeting a sebaceous gland by redistributing the solution of unassembled plasmonic nanoparticles from the skin surface to the sebaceous gland with a delivery device;
• wherein the delivery device is a sonic mechanical vibration device;
• wherein the unassembled plasmonic nanoparticles have a dimension in a range of 10 nm to 300 nm,
• wherein the unassembled plasmonic nanoparticles comprise a conductive metal portion,
• wherein the conductive metal portion comprises at least one of gold or silver,
• wherein the unassembled plasmonic nanoparticles comprise a coating that coats the conductive metal portion, wherein said coating facilitates selective removal from the skin surface;
• wherein the coating comprises at least one of silica or polyethylene glycol (PEG),
• selectively removing the solution from the skin surface, while leaving the solution localized within the sebaceous gland;
• and
• irradiating the solution of unassembled plasmonic nanoparticles with an energy wavelength in a range of 750 nm to 1200 nm to induce a plurality of surface plasmons in said unassembled plasmonic nanoparticles to cause ablation in the sebaceous gland, thereby treating acne at said sebaceous gland.

A method of delivering a composition of unassembled plasmonic nanoparticles to a pilosebaceous unit and performing ablation, comprising:

• applying a solution of unassembled plasmonic nanoparticles to a skin surface,
• distributing the solution of unassembled plasmonic nanoparticles with a mechanical vibration device from the skin surface to a pilosebaceous unit thereby targeting the pilosebaceous unit,
• wherein the mechanical vibration device comprises at least one of the group consisting of a sonic force device, a high pressure air flow device, a high pressure liquid flow device, a vacuum device, and a dermabrasion device,
• wherein the pilosebaceous unit comprises one or more structures consisting of:
• a hair shaft, a hair follicle, a sebaceous gland, and a hair follicle infundibulum;
• wherein the unassembled plasmonic nanoparticles comprise a conductive metal portion,
• wherein the conductive metal portion comprises at least one of gold or silver;
• wherein the unassembled plasmonic nanoparticles have a peak absorption wavelength of between 750 nm and 1200 nm,
• wherein the unassembled plasmonic nanoparticles comprise a coating that coats the conductive metal portion,
• wherein the coating comprises at least one of silica or polyethylene glycol (PEG),
• selectively removing the solution from the skin surface while leaving the solution localized within the portion of the sebaceous gland, and
• irradiating the solution with an energy to induce said unassembled plasmonic nanoparticles to generate localized ablation, wherein said ablation comprises thermal damage in said sebaceous gland.