Compound and method
AssigneePCI Biotech AS
InventorsAnders Høgset, Pål Johansen
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Abstract
The present invention provides a method of expressing an antigenic molecule or a part thereof on the surface of a cell using a photochemical internalization method in which a cytokine, preferably GM-CSF, is used to enhance the method. The method may be used to stimulate an immune response and for various therapeutic or prophylactic methods. Pharmaceutical compositions or kits comprising the components for use in the method, cells produced by the method and their use in therapy and prophylaxis also form aspects of the invention.
Claims28
A method of generating an immune response in a subject, comprising administering to said subject an antigenic molecule, a photosensitizing agent, and a cytokine, and irradiating said subject with light of a wavelength effective to activate said photosensitizing agent, wherein an immune response is generated.
A method of generating an immune response in a subject, comprising preparing a population of cells and subsequently administering said cells to said subject,
- wherein said population of cells is prepared by contacting a population of cells with an antigenic molecule, a photosensitising agent, and a cytokine, and irradiating said cells with light of a wavelength effective to activate the photosensitising agent, whereupon said antigenic molecule is released into the cytosol of the cell and the antigenic molecule or a part thereof is subsequently presented on the surface of the cell.
Dependencies are inferred from the claim text.