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US 10,537,618 B2Granted
Prohemostatic proteins for the treatment of bleeding
AssigneeAcademisch Ziekenhuis Leiden
InventorsDaniël Verhoef, Pieter H. Reitsma, Mettine H. A. Bos
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Abstract
This disclosure relates to recombinant FXa polypeptides that can be used as antidotes to completely or partially reverse an anti-coagulant effect of a coagulation inhibitor in a subject, preferably a direct factor Xa inhibitor. Disclosed herein are recombinant factor Xa proteins and a method of completely or partially reversing an anti-coagulant effect of a coagulation inhibitor in a subject.
Claims12
A recombinant protein comprising:
- the polypeptide of SEQ ID NO:1 having an alteration in a region of amino acid residues corresponding to the region of amino acid residues between His-311 and Asp-320 of SEQ ID NO:
- 1, wherein the alteration is a replacement of the amino acid residues Asn-312 through Tyr-319of SEQ ID NO:
- 1 with the amino acid sequence selected from the group consisting of SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 9, SEQ ID NO:
- 10, and SEQ ID NO:
- 11.
5 more elements
Dependencies are inferred from the claim text.