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US 10,537,615 B2Granted
IL-15-based molecules and methods of use thereof
AssigneeAltor BioScience Corporation
InventorsBai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
Life of this patent
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Abstract
The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
Claims7
A method for killing diseased cells expressing a target antigen, the method comprising:
- treating immune cells with an effective amount of an IL-15N72D:IL-15RaSu/Fc complex (ALT-803),
- mixing the ALT-803-treated immune cells with an antibody specific to a target antigen and diseased cells expressing said target antigen,
- killing the diseased cells via ADCC or ADCP mediated by the ALT-803-treated immune cells and target antigen-specific antibody.
Dependencies are inferred from the claim text.