Monomeric CXCL121 peptide and methods of treating autoimmune diseases
AssigneeThe Medical College of Wisconsin, Inc.
InventorsBrian Volkman, Joshua Ziarek, Christopher Veldkamp, Francis Peterson
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Abstract
The present invention provides a CXCL121 peptide engineered to resist peptide-induced dimerization by maintaining steric repulsion of the chemokine helix, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and HIV/AIDS.
Claims8
A method of treating inflammation associated with an autoimmune disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a composition comprising a constitutively monomeric CXCL12 peptide comprising the amino acid sequence of SEQ ID NO:1 wherein the amino acids at positions 55 and 58 are substituted with cysteine, effective to reduce inflammation in the subject.
A method of treating inflammation associated with an inflammatory bowel disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a composition comprising a constitutively monomeric CXCL12 peptide comprising the amino acid sequence of SEQ ID NO:1 with amino acids at positions 55 and 58 substituted with cysteine, effective to reduce inflammation associated with inflammatory bowel disease in the subject.
Dependencies are inferred from the claim text.