Adiponectin peptidomimetics for treating ocular disorders
AssigneeAllysta Pharmaceuticals, Inc.
InventorHenry Hsu
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Abstract
Provided herein are compositions and methods for treating dry eye or an ocular disease associated with inflammation in a subject in need thereof. The therapeutic compositions comprise an adiponectin peptidomimetic compound, and a pharmaceutically acceptable carrier, and administering a therapeutic agent. Also provided are methods for alleviating one or more symptoms or clinical signs of dry eye or an ocular disease associated with inflammation in a subject in need thereof.
Claims16
A method for treating dry eye in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a composition comprising:
- an adiponectin peptidomimetic compound, Lifitegrast and a pharmaceutically acceptable carrier, to treat dry eye in the subject, wherein the adiponectin peptidomimetic compound is represented by Formula II:
- Xaai-Ile-Pro-Xaa2-Leu-Tyr-Xaa3-Phe-Ala-Xaa4-Xaa5 (SEQ ID NO:1), wherein Xaai is Asn or a non-natural amino acid, Xaa2 is Gly or a non-natural amino acid, Xaa3 is Tyr or a non-natural amino acid, Xaa4 is Tyr or a non-natural amino acid, and Xaa5 is no amino acid, β-Ala or P-Ala-NH2, wherein the C-terminal amino acid is optionally amidated, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.