Back to results
US 10,537,595 B2Granted
Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
AssigneeIovance Biotherapeutics, Inc.
InventorsSeth Wardell, James Bender, Michael T. Lotze
Life of this patent
Estimating the term…
Abstract
The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
Claims22
An expanded tumor infiltrating lymphocyte (TL) composition comprising:
- i) a therapeutic population of tumor infiltrating lymphocytes (TILs), wherein said therapeutic population comprises expanded TILs, and
- ii) a cryopreservant;
- wherein the therapeutic population of TILs exhibits increased IFN-γ secretion by at least one-fold in vitro as compared to a non-expanded population of TILs.
Dependencies are inferred from the claim text.