Methods for the treatment and prophylaxis of HIV and AIDS
AssigneeMerck Sharp & Dohme Corp.
InventorsDaria Hazuda, Michael D. Miller, Jay A. Grobler, Deborah Anne Nicoll-Griffith
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Abstract
The present invention is directed to methods for inhibition of HIV reverse transcriptase, treatment of infection by HIV, prophylaxis of infection by HIV, and the treatment, prophylaxis and/or delay in the onset or progression of AIDS or ARC by administering a compound of structural Formula I or a pharmaceutically acceptable salt or co-crystal thereof, wherein X is —F or —Cl, less frequently than once daily.
Claims32
A method for the prophylaxis of HIV infection in a subject which comprises orally administering to the subject an effective amount of a compound of structural formula:
- or a pharmaceutically acceptable salt thereof, wherein the dosing regimen is once-weekly, bi-weekly, twice monthly or once-monthly.
A method for the prophylaxis of HIV infection in a subject which comprises orally administering to the subject an effective amount of a compound of structural formula:
- wherein the dosing regimen is once-weekly, bi-weekly, twice monthly or once-monthly.
Dependencies are inferred from the claim text.