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US 10,537,586 B2Granted
System and method for diagnosis and treatment
AssigneePop Test Oncology LLC
InventorsRandice Lisa Altschul, Neil David Theise, Myron Rapkin, Rebecca O'Brien
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Abstract
This invention relates the use of cortisol blockers (glucocorticoid receptor [GR] antagonists) for the treating or preventing treatment resistant prostate cancer, treating or preventing neoplasia, and treating or preventing infection related to acute or chronic injury or disease.
Claims30
A method for treating neoplasia characterized by expression of a glucocorticoid receptor, in a patient in need of such treatment, comprising:
- administering to said patient at least one therapeutically effective neoplasia-treating therapy, and
- wherein the GCR antagonist is ORG34517 ((11β,17β)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-17-(1-propynyl) estra-4,9-dien-3-one) which has the following formula:
- wherein the administration of ORG 34517 for GR-blockade, reduces toxicities and side effects when given systemically,
- thereby treating said animal or human.
1 more element
A method for treating neoplasia in a patient in need of such treatment, the method comprising:
- a) administering to said patient a therapeutically effective amount of ORG 34517;
- and
- b) administering to said patient at least one therapeutically effective neoplasia-treating therapy,
- thereby treating said patient.
1 more element
Dependencies are inferred from the claim text.