Azocane and azonane derivatives and methods of treating hepatitis B infections

A method of reducing the viral load associated with an HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of a compound of Formula I:

• or a pharmaceutically acceptable salt thereof;
• wherein
• R4 is H or C1-C3 alkyl;
• R1 is, independently at each occurrence, —OH, halo, —CN, —NO2, —H2PO4, —C1-C6 alkyl, —O—C1-C6 alkyl, —C1-C6 heteroalkyl, —O—C1-C6 heteroalkyl, —C3-C10 cycloalkyl, —C3-C10 heterocycloalkyl, C6-C10 aryl, C5-C9 heteroaryl, —C1-C4 alkyl-(C3-C10 cycloalkyl), —C1-C4 alkyl-(C3-C10 heterocycloalkyl), —C1-C4 alkyl-(C6-C10 aryl), or —C1-C4 alkyl-(C5-C9 heteroaryl), wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl groups are optionally substituted 1-5 times with halo, —OH, —CN, or —NO2;
• R2 is, independently at each occurrence, —OH, halo, —CN, —NO2, R6, or OR6, wherein R6 is, independently at each occurrence, —C1-C6 alkyl, —C1-C6 heteroalkyl, —C3-C10 cycloalkyl, —C3-C10 heterocycloalkyl, C6-C10 aryl, C5-C10 heteroaryl, —C1-C4 alkyl-(C3-C10 cycloalkyl), —C1-C4 alkyl-(C3-C10 heterocycloalkyl), —C1-C4 alkyl-(C6-C10 aryl), or —C1-C4 alkyl-(C5-C10 heteroaryl), wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl groups are optionally substituted 1-5 times with halo, —OH, —CN, or —NO2;
• Cy is
• wherein
• R11 is, independently at each occurrence, —OH, halo, —CN, —NO2, —C1-C6 alkyl, —O—C1-C6 alkyl, —C1-C6 heteroalkyl, —O—C1-C6 heteroalkyl, —C3-C10 cycloalkyl, —C3-C10 heterocycloalkyl, C6-C10 aryl, C5-C9 heteroaryl, —C1-C4 alkyl-(C3-C10 cycloalkyl), —C1-C4 alkyl-(C3-C10 heterocycloalkyl), —C1-C4 alkyl-(C6-C10 aryl), or —C1-C4 alkyl-(C5-C9 heteroaryl), wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl groups are optionally substituted 1-5 times with halo, —OH, —CN, or —NO2, or two R11 groups, together with the carbons to which they are attached, join to form a cyclic phosphate ring;
• m is 0, 1, 2, 3, or 4;
• x is 0, 1, 2, 3, 4, or 5;
• and
• y is 0, 1, 2, 3, or 4.