Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
AssigneeVertex Pharmaceuticals Incorporated
InventorsPatricia Hurter, William Rowe, Christopher R. Young, Adriana Costache, Patrick R. Connelly, Mariusz Krawiec, Yuchuan Gong, Yushi Feng, Martin Trudeau
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Abstract
The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
Claims26
A crystal form of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, having at least one peak within a 2θ value range selected from 6.0 to 6.4, 10.8 to 11.2, 16.9 to 17.3, 19.2 to 19.6, 20.9 to 21.3, 22.4 to 22.8, 26.5 to 26.9 and 27.3 to 27.7 degrees in an X-ray powder diffraction pattern obtained using Cu K alpha radiation.
A crystal form of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, having a monoclinic crystal system, a P21 space grouping, and the following unit cell dimensions:
- a=11.8011(7) Å α=90°
- b=5.9819(3) Å β=105.110(4)°
- c=14.7974(8) Å γ=90°.
A crystal form of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, having an X-ray powder diffraction pattern, obtained using Cu K alpha radiation, substantially similar to FIG. 7.
Dependencies are inferred from the claim text.