Methods of treating underlying inflammation from COPD or asthma
AssigneeMEDA Pharma GmbH & Co. KG
InventorsJoachim Goede, Joachim Maus, Peter Jürgen Cnota, Istvan Szelenyi
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Abstract
The present invention describes the combination of topically inhaled medicinal formulations comprising an anticholinergic component and a glucocorticosteroid component and its use in the symptomatic and prophylactic treatment of diseases of the respiratory tract, especially with an obstructive component or underlying inflammation like asthma and chronic obstructive pulmonary disease (COPD). It further comprises the presentation of this combination in a locally applied (inhaled) formulation and application in an inhalation device for instance in the NOVOLIZER®.
Claims14
A method of treating underlying inflammation caused by chronic obstructive pulmonary disease (COPD) or asthma in a mammal, comprising:
- administering an effective amount of a pharmaceutical composition comprising synergistically effective amounts of R,R-glycopyrrolate and budesonide, or physiologically acceptable salts thereof, to said mammal,
- wherein treating inflammation caused by COPD or asthma results in an inhibition of TNFα release from a peripheral blood mononuclear cell (PBMC) of said mammal,
- wherein the inhibition of TNFα release from the PBMC of said mammal caused by the administration of the pharmaceutical composition is greater than inhibition of TNFα release from a PBMC of said mammal caused by administration of R,R-glycopyrrolate or budesonide alone, as measured by enzyme-linked immunosorbent assay (ELISA).
A method of inhibiting TNFα release from an isolated peripheral blood mononuclear cell (PBMC), comprising:
- administering an effective amount of a pharmaceutical composition comprising synergistically effective amounts of R,R-glycopyrrolate and budesonide, or physiologically acceptable salts thereof, to the isolated PBMC, and
- inhibiting TNFα release from the isolated PBMC, wherein the inhibition of TNFα release by the administration of the pharmaceutical composition is greater than inhibition of TNFα release by administration of R,R-glycopyrrolate or budesonide alone.
Dependencies are inferred from the claim text.