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US 10,537,545 B2Granted
Ceramide derivatives as anticancer agents
AssigneeRutgers, The State University of New Jersey
InventorsRichard Lutz, Eric Andrianasolo, Paul Falkowski, Eileen White, Liti Haramaty
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Abstract
The invention provides a compound of formula (I): (I) wherein R1-R4 have any of the values defined in the specification, as well as compositions comprising a compound of formula (I) and methods for treating diseases (e.g. cancer).
Claims20
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is Ra—(OCH2CH2)n—;
- R2 is (C4-C25)alkyl or (C4-C25)alkenyl;
- R3 is (C4-C25)alkyl or (C4-C25)alkenyl;
- R4 is (C4-C25)alkyl or (C4-C25)alkenyl;
- Ra is (C1-C6)alkyl;
- and
- n is 0, 4, 5, 6, 7, 8, 9, or 10.
5 more elements
A method for treating cancer in an animal comprising administering to the animal:
- 1) an anticancer compound, and 2) a compound of formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is Ra—(OCH2CH2)n—;
- R2 is (C4-C25)alkyl or (C4-C25)alkenyl;
- R3 is (C4-C25)alkyl or (C4-C25alkenyl;
- R4 is (C4-C25)alkyl or (C4-C25)alkenyl;
- Ra is (C1-C6)alkyl;
- and
- n is 0, 4, 5, 6, 7, 8, 9, or 10.
6 more elements
Dependencies are inferred from the claim text.