Methods of treating hypertriglyceridemia
AssigneeAmarin Pharmaceuticals Ireland Limited
InventorsMehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Abstract
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
Claims7
A method of reducing large vLDL particle concentration in a subject having a fasting baseline triglyceride level of about 500 mg/dl to about 1500 mg/dl and a baseline large vLDL particle concentration of about 20 nmol/L to about 40 nmol/L, comprising administering to the subject about 4 g per day ethyl eicosapentaenoate for a period of 12 weeks thereby to produce a reduction in large vLDL particle concentration, wherein the large vLDL particle has a diameter of greater than 60 nm.
Dependencies are inferred from the claim text.