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US 10,537,533 B2Granted
Low-temperature inhalation administration of cannabinoid entities
AssigneeEP Pharma, LLC
InventorsCharles Raymond Eck, Christopher L. Pelloni
Life of this patent
Estimating the term…
Abstract
A cannabinoid material as active agent containing formulation comprising the active agent, an HFA propellant, and optionally a co-solvent is disclosed. Also disclosed is an inhalation method of administration of the formulation without the use of heat greater than 50° C.
Claims21
A cannabinoid component containing formulation comprising:
- (a) said cannabinoid component comprising one or more cannabinoid active agent(s)
- (i) at least one of said one or more cannabinoid active agent(s) is not selected from the group consisting of tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), cannabidiolic acid (CBDA) or salts thereof and
- (ii) optionally zero or one or more cannabinoids selected from the group consisting of tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), cannabidiolic acid (CBDA), esters, amides, and salts thereof;
- (b) a hydrofluoroalkane (HFA) propellant;
- and
- (c) a co-solvent for said cannabinoid active agent, which co-solvent is ethanol;
- said HFA propellant being present in an amount of from 50% by weight to 99.99% by weight based on the entire formulation;
- said co-solvent, being present in an amount of from 0.1% by weight up to 40% by weight based on the entire formulation;
- and
- said cannabinoid active agent being present, in an amount 0.01 mg/100 ul to 20 mg/100 ul relative to the total formulation when only a single cannabinoid is present, and based on the total of the two most predominantly present cannabinoid active agents present of 0.01 mg/100 ul to 20 mg/100 ul of total formulation, when more than one cannabinoid is present;
- wherein the only active agents present in said formulation are (a) cannabinoid active agents and (b) noncannabinoid active agents which noncannabinoid active agents are otherwise naturally present in extracts of cannabinoid containing plant materials;
- and
- wherein glycerol is not present in said formulation.
10 more elements
A cannabinoid component containing formulation consisting of:
- (a) said cannabinoid component consisting of
- (I) one or more cannabinoid active agent(s)
- (i) at least one of said one or more cannabinoid active agent(s) is not selected from the group consisting of tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), cannabidiolic acid (CBDA) or salts thereof and
- (ii) optionally zero or one or more cannabinoids selected from the group consisting of tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), cannabidiolic acid (CBDA), esters, amides, and salts thereof;
- (II) optionally non-cannabinoid active agents and inactive agents, each of said non-cannabinoid active agents and inactive agents being selected from the group consisting of those naturally found in extracts of cannabinoid containing plant materials;
- (b) a hydrofluoroalkane (HFA) propellant;
- and
- (c) a co-solvent for said cannabinoid active agent, which co-solvent is selected from the group consisting of ethanol;
- said HFA propellant being present in an amount of from 50% by weight to 99.99% by weight based on the entire formulation;
- said co-solvent, being present in an amount of from 0.1% by weight up to 40% by weight based on the entire formulation;
- and
- said cannabinoid active agent being present, in an amount 0.01 mg/100 ul to 20 mg/100 ul relative to the total formulation when only a single cannabinoid is present, and based on the total of the two most predominantly present cannabinoid active agents present of 0.01 mg/100 ul to 20 mg/100 ul of total formulation, when more than one cannabinoid is present;
- wherein glycerol is not present in said formulation.
10 more elements
Dependencies are inferred from the claim text.