Solid dosage forms comprising an enteric coating with accelerated drug release

A gastric resistant, enteric-coated solid dosage form comprising

• an inner coating located between a core containing a pharmaceutically active ingredient and an outer enteric coating;
• wherein said inner coating further comprises at least one water soluble inorganic salt, wherein the cation of the inorganic salt is selected from the group consisting of alkali metal, alkaline earth metal, ammonium, manganese, iron, copper, zinc, and molybdenum cations, and the anion of the inorganic salt is selected from the group consisting of chloride, fluoride, bromide, iodide, nitrate, nitrite, and sulphate anions, with the proviso that carbonates and bicarbonates are excluded;
• and
• wherein the inner coating comprises a partially neutralized anionic (meth)acrylate copolymeric material and the outer coating comprises the same partially neutralized anionic (meth)acrylate copolymeric material of the inner coating, with the proviso that the partially neutralized anionic (meth)acrylate copolymeric material of the outer coating is less neutralized than the partially neutralized anionic (meth)acrylate copolymeric material of the inner coating.

A gastric resistant, enteric-coated solid dosage form comprising

• an inner coating located between a core containing a pharmaceutically active ingredient and an outer enteric coating;
• wherein said inner coating further comprises at least one water soluble inorganic salt, wherein the cation of the inorganic salt is selected from the group consisting of alkali metal, alkaline earth metal, ammonium, manganese, iron, copper, zinc, and molybdenum cations, and the anion of the inorganic salt is selected from the group consisting of chloride, fluoride, bromide, iodide, nitrate, nitrite, and sulphate anions, with the proviso that carbonates and bicarbonates are excluded;
• and
• wherein each of the outer and the inner coating comprises a partially neutralized anionic (meth)acrylate copolymer consisting of free-radical polymerized units of 25 to 95% by weight C1- to C4-alkyl esters of acrylic or of methacrylic acid and 5 to 75% by weight (meth)acrylate monomers having an anionic group, wherein the outer coating is less neutralized than the inner coating.

A gastric resistant, enteric-coated solid dosage form comprising

• an inner coating located between a core containing a pharmaceutically active ingredient and an outer enteric coating;
• wherein said inner coating further comprises at least one water soluble inorganic salt, wherein the cation of the inorganic salt is selected from the group consisting of alkali metal, alkaline earth metal, ammonium, manganese, iron, copper, zinc, and molybdenum cations, and the anion of the inorganic salt is selected from the group consisting of chloride, fluoride, bromide, iodide, nitrate, nitrite, and sulphate anions, with the proviso that carbonates and bicarbonates are excluded;
• and
• wherein the inner coating comprises a partially neutralized anionic (meth)acrylate copolymeric material and the outer coating consists essentially of the same partially neutralized anionic (meth)acrylate copolymeric material of the inner coating, with the proviso that the partially neutralized anionic (meth)acrylate copolymeric material of the outer coating is less neutralized than the partially neutralized anionic (meth)acrylate copolymeric material of the inner coating.