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US 10,537,525 B2Granted
Methods and materials for delivering agents to liver tissue
AssigneeMayo Foundation for Medical Education and Research
InventorDouglas O. Faigel
Life of this patent
Estimating the term…
Abstract
This document provides methods and materials for delivering agents to liver tissue. For example, methods and materials for using microbeads to deliver agents (e.g., chemotherapeutic agents) to liver tissue are provided.
Claims22
A method for delivering an agent to liver tissue, wherein said method comprises:
- (a) advancing an endoscope device configured with a needle into the stomach or duodenum of a mammal under endoscopic ultrasound guidance,
- (b) advancing said needle out of said stomach or duodenum and into a portal vein of said mammal, and
- (c) administering a solution containing said agent into said portal vein,
- wherein the concentration of said agent within liver tissue of said mammal following said administering step is greater than the concentration of said agent within liver tissue when the same amount of said agent is administered to the jugular vein of a control mammal.
1 more element
A method for delivering an agent to liver tissue, wherein said method comprises:
- (a) advancing an endoscope device configured with a needle into the stomach or duodenum of a mammal under endoscopic ultrasound guidance,
- (b) advancing said needle out of said stomach or duodenum and into a portal vein of said mammal, and
- (c) administering a solution containing microbeads comprising said agent into said portal vein,
- wherein the concentration of said agent within liver tissue of said mammal following said administering step is greater than the concentration of said agent within liver tissue when the same amount of said agent is administered to the jugular vein of a control mammal without microbeads.
1 more element
Dependencies are inferred from the claim text.