Apixaban solid composition and preparation method thereof
AssigneeNorth & South Brother Pharmacy Investment Company Limited
InventorsQibiao Huang, Xin Huang, Fangfang Huang, Jinsong You, Feng Zhao
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Abstract
The present invention provided an apixaban solid composition and a preparation method thereof. The method comprises granulating apixaban by wet granulation, wherein the apixaban has a particle size D90 more than 89 μm.
Claims24
An apixaban solid composition comprising apixaban having a particle size D90 more than 89 μm, wherein the apixaban is dissolved in a wetting agent, wherein the wetting agent is an acidic substance or an organic solvent.
An apixaban solid composition comprising 2.50 parts by weight of apixaban, 33.50 to 63.50 parts by weight of lactose anhydrous, 24.00 to 54.00 parts by weight of microcrystalline cellulose, 2.00 to 8.00 parts by weight of croscarmellose sodium, 2.00 to 8.00 parts by weight of povidone, 0.50 to 4.00 parts by weight of sodium dodecyl sulfate and 0.50 to 2.50 parts by weight of magnesium stearate, wherein the apixaban has a particle size D90 more than 89 μm or between 100 μm and 550 μm, wherein the apixaban solid composition further comprises a wetting agent, and wherein the wetting agent is an acidic substance or an organic solvent.
A method of preparing an apixaban composition comprising:
- granulating apixaban by using a wet granulation method, and dissolving apixaban in a wetting agent, wherein the wetting agent is an acidic substance or an organic solvent, and wherein the apixaban has a particle size D90 more than 89 μm.
Dependencies are inferred from the claim text.