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US 10,537,518 B2Granted
Homogenization system of drugs into biodegradable polymer: smart polymer system
AssigneeJuvic Inc.
InventorsHyung Il Jung, Dangol Manita
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AssigneeJuvic Inc.
InventorsHyung Il Jung, Dangol Manita
Estimating the term…
A viscous composition for transdermal drug delivery, a method of preparing the same, and a microstructure device prepared using the viscous composition are provided. Here, the viscous composition includes colloidal particles formed of a combination of a drug and a biodegradable polymer, and the biodegradable polymer includes a first amphiphilic polymer. The use of a solvent can be minimized to homogenize the drug in the biodegradable polymer including the first amphiphilic polymer, thereby forming colloidal particles. Therefore, since a separate solvent cannot be used, the microstructure device is expected to be a transdermal drug delivery system which is safe, efficient or useful for drugs which do not include a proper solvent, show poor bioavailability or have a high molecular weight.
A viscous composition for transdermal drug delivery, comprising colloidal particles formed of a combination of a lipophilic drug and a biodegradable polymer comprising polyvinyl pyrrolidone (PVP) and hyaluronic acid (HA), wherein the weight ratio of PVP to HA ranges from 20:1 to 1:20, wherein the lipophilic drug is bound to the polyvinyl pyrrolidone (PVP), and wherein the lipophilic drug is homogenized in the biodegradable polymer without a solubilizing solvent for the lipophilic drug.
A method of preparing a viscous composition for transdermal drug delivery, comprising:
A microstructure device comprising:
Dependencies are inferred from the claim text.