Methods and apparatus for therapeutic application of thermal energy including blood viscosity adjustment

Apparatus for treating a condition of a human, the apparatus comprising:

• an appendage chamber configured to accept a human appendage containing an arteriovenous anastomosis (AVA);
• a thermal exchange member disposed within the appendage chamber, the thermal exchange member configured to selectively heat or cool blood flowing through the AVA;
• a sensor coupled to the thermal exchange member, the sensor configured to measure a force of the appendage applied to the thermal exchange member;
• a user interface;
• and
• a programmable controller configured to cause the apparatus to enter a game mode responsive to input received at the user interface, the programmable controller further configured to monitor the force of the appendage applied to the thermal exchange member, to calculate a score based on the monitored force, and to cause the user interface to display the score during the game mode, the programmable controller further configured to calculate the score using a lookup table stored in a memory of the programmable controller, the memory including scores for corresponding force ranges relative to a calibrated base force of a user,
• wherein the score increases as time within a desired force range increases.