Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds

A device for ablating target tissue cells comprising:

• a first electrode adapted for insertion into a first blood vessel associated with target tissue cells and adapted to be in contact with fluid inside the first blood vessel;
• a voltage source adapted to apply a plurality of electrical pulses to the first electrode so as to deliver ablation energy to the target tissue cells using the fluid inside the first blood vessel an electrical conduit;
• further comprising a second electrode whereby the plurality of electrical pulses are applied between the first and second electrodes, wherein:
• the voltage source is adapted to generate the plurality of electrical pulses in an amount sufficient to ablate the target tissue cells by irreversible electroporation (IRE);
• the first and second electrodes are adapted for insertion respectively into an artery and a vein;
• and
• further comprising a first connection device adapted for connection with the first blood vessel, the first connection device having a one-way valve adapted to electrically isolate the target tissue cells between heart beats.

A device for ablating target tissue cells comprising:

• a first connection device adapted for connection with a first blood vessel;
• a first electrode having an exposed portion disposed within the first connection device and adapted to be in contact with fluid inside the first blood vessel;
• and
• a voltage source adapted to apply a plurality of electrical pulses to the first electrode so as to deliver ablation energy to target tissue cells using the fluid inside the first blood vessel an electrical conduit;
• wherein the first connection device comprises a one-way valve adapted to electrically isolate the target tissue cells between heart beats.